منابع مشابه
Simulation and Automatic Design of Nucleic Acid Reaction System
I propose an efficient simulation technique for analyzing biological reactions and an automatic design method for developing artificial reactions, both of which are targeted to systems mainly composed of nucleic acids. DNA that is one type of nucleic acids is utilized as a genetic information carrier in biology, while RNA that is the other type of nucleic acids has a biological functionality be...
متن کاملHybridization and reaction-based fluorogenic nucleic acid probes.
We developed fluorogenic probes, which are photoactivated in the presence of specific nucleic acid templates with the release of fluorescent dyes. This templated reaction can be used to target specific nucleic acids in complex mixtures. We further demonstrate that this reaction can be monitored by single-molecule fluorescence imaging.
متن کاملNucleic Acid Templated Chemical Reaction in a Live Vertebrate
Nucleic acid templated reactions are enabled by the hybridization of probe-reagent conjugates resulting in high effective reagent concentration and fast chemical transformation. We have developed a reaction that harnesses cellular microRNA (miRNA) to yield the cleavage of a linker releasing fluorogenic rhodamine in a live vertebrate. The reaction is based on the catalytic photoreduction of an a...
متن کاملConstrained Multistate Sequence Design for Nucleic Acid Reaction Pathway Engineering.
We describe a framework for designing the sequences of multiple nucleic acid strands intended to hybridize in solution via a prescribed reaction pathway. Sequence design is formulated as a multistate optimization problem using a set of target test tubes to represent reactant, intermediate, and product states of the system, as well as to model crosstalk between components. Each target test tube ...
متن کاملEffective molarity in a nucleic acid-controlled reaction.
Positioning of reactive functional groups within a DNA duplex can enable chemical reactions that otherwise would not occur to an appreciable extent. However, few studies have quantitatively defined the extent to which the enforced proximity of reaction partners in duplex DNA can favor chemical processes. Here, we measured substantial effective molarities (as high as 25M) afforded by duplex DNA ...
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ژورنال
عنوان ژورنال: Archivum histologicum japonicum
سال: 1955
ISSN: 0004-0681
DOI: 10.1679/aohc1950.8.81